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. 2019 Aug 15;9:11918. doi: 10.1038/s41598-019-48427-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Volcano plot of the genes differentially expressed in purified endothelial cells. Yellow represents 18997 genes that were not modified; grey, the 297 genes with expression decreased from 1.5 to 2-fold; orange, the 30 genes with expression decreased more than 2-fold; dark blue, the 682 genes with expression increased from 1.5 to 2-fold; light blue, the 140 genes with expression induced more than 2-fold. (B) Clustering by Gene Set Enrichment Analysis of the 20146 genes analyzed in the microarray analysis. The figure represents the 6 most significant pathways; the complete list (with the default threshold fixed at false discovery rate <0.25) is in Supplementary Fig. 2. Pathways of stress and inflammation are considerably enriched in upregulated genes, for a marked pro-inflammatory status of endothelial cells in mice with preeclampsia 8 months earlier versus mice with a normotensive pregnancy.