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. 2019 Aug 15;9:11929. doi: 10.1038/s41598-019-47457-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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P. aeruginosa QS molecules disrupt mitochondrial morphology in bronchial epithelial cells. BEAS-2B cells were treated with vehicle control (DMSO), 100 μM 3-oxo-C12-HSL (C12-HSL), or infected with PAO1 (MOI 20) for 6 hours. Cells were then fixed and processed for electron microscopy (EM) analysis. (A) representative high-powered field (hpf) images of treatment groups, 15,000x magnification, scale 0.2 μm. (B) number of mitochondria per hpf. (C) Total mitochondrial area per hpf. (D) Mitochondrial length to width ratio. 3-oxo-C12-HSL and PAO1 disrupt mitochondrial morphologic parameters. Results are mean ± SEM. *P < 0.05, **p < 0.01, ****p < 0.0001 all vs. control. One-way ANOVA with Tukey’s multiple comparisons test used for statistical analysis.