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. 2019 Aug 15;9:11877. doi: 10.1038/s41598-019-48425-5

Table 1.

Key characteristics of eligible trials.

Number of eligible studies 163
Range of publication years 1982–2017
Study type #
     Singly tested small molecules 82
     Singly tested biologics 21
     Biologics and/or small molecules in combination 29
     Surgical intervention 16
     Radiation therapy 27
     Dietary regimen/feeding behavior 8
     Diagnostic procedure 1
Number of studies per ACS tumor type*
     Bone 32
     Digestive 12
     Endocrine 5
     Eye 3
     Genital 10
     Leukemia 2
     Lymphoma 53
     Mammary 28
     Mastocytoma 22
     Nervous 8
     Not reported 23
     Oral 19
     Other 25
     Respiratory 4
     Skin 27
     Soft tissue 29
     Urinary 12

*Each trial may have investigated multiple tumor types.

#Each trial may have investigated multiple intervention types.