Table 1.
Average isotopic composition of brain and serum samples. Numbers indicated correspond to mean +/− SD of δ65Cu (number of mice). nd, not determined.
| Serum 3 months | Serum 6 months | Serum 9 months | Serum 12 months | Brain 12 months | ||
|---|---|---|---|---|---|---|
| Wild type | Males | −0.74 +/− 0.09 (n = 4) | −0.74 +/− 0.22 (n = 5) | −0.89 +/− 0.09 (n = 4) | nd (n = 0) | nd (n = 0) |
| Females | −0.51 +/− 0.11 (n = 5) | −0.48 +/− 0.23 (n = 5) | −0.54 +/− 0.23 (n = 5) | −0.31 +/− 0.19 (n = 5) | 0.63 +/− 0.26 (n = 5) | |
|
APPswe/ PSEN1dE9 |
Males | −0.78 +/− 0.23 (n = 5) | −0.76 +/− 0.04 (n = 7) | −0.70 +/− 0.19 (n = 7) | −0.65 +/− 0.08 (n = 3) | nd (n = 0) |
| Females | −0.49 +/− 0.25 (n = 5) | −0.53 +/− 0.20 (n = 6) | −0.56 +/− 0.23 (n = 4) | −0.59 +/− 0.28 (n = 5) | 0.51 +/− 0.15 (n = 5) | |