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. 2019 Aug 15;9:11922. doi: 10.1038/s41598-019-47462-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of donepezil on non-amyloidogenic processing of APP in primary cortical cells. Cells were treated with 1 μM donepezil for 72 h. Cell lysate and culture media were subjected to western blotting. Representative images of western blotting analysis (a) and quantification of sAPPα (b) and APP/β-actin ratio (c) are shown. The grouping of blots was cropped from different parts of the same gel. *P < 0.05 compared with control cells. n.s., not significant. Data are expressed as mean ± SEM of n = 6 independent observations. APP, amyloid precursor protein.