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. 2019 Aug 15;9:11878. doi: 10.1038/s41598-019-48047-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mitophagic flux is damaged in sacsin KO cells. (A,B) Representative images of WT and KO cells immunolabeled for PINK1 (green) and Parkin (red) under normal conditions (A,C) or FCCP treatment (B,D) showed loss of co-localization of PINK1 with Parkin in KO cells compared to WT cells, indicating a defective mitophagic flux. Co-localization of PINK1 with Parkin (rounded structures) is arrow indicated (the insert shows an enlargement of these structures). DAPI (in blue) was used as nuclear stain. Scale bar = 10 µm.