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. 2019 Aug 15;9:11890. doi: 10.1038/s41598-019-48347-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Model representations and computed CMR (red asterisks (*)) against mass for (A) shell-free constructs. (B) Constructs with a hydrogel shell; (C) constructs with a hydrogel shell and a micro-vessel. The experimental range of organoid masses in Table 1 are black diamonds (w). Blue dotted line: least squares fit for the experimental range of masses. Blue full line: best fit. The slopes (b) and corresponding R² values are indicated in the plots.