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. 2019 Aug 15;9:11893. doi: 10.1038/s41598-019-48174-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LEAP does not disrupt cardiomyocyte function or behavior. (a) FPs were recorded before and 48 hours after LEAP induction on all electrodes of a Classic MEA 96-well plate with iCell CM². The FP was not affected by LEAP induction. (b) FPDc before and after LEAP were tightly correlated (R² = 0.84, p < 0.001). Each dot represents the FPDc before and 48 hours after LEAP induction for a well, with the unity line in black for comparison. (c) Here, LEAP induction was applied to half of the electrodes in half of the wells on a Classic MEA 96-well plate with iCell CM². FPs were recorded before and 60 minutes after LEAP induction. Bar plots represent the percent change (mean ± standard deviation across wells) in BP and FPDc, measured from the FP signal, from before to 60 minutes post-LEAP induction. Changes in BP and FPD did not differ between control (no LEAP) and LEAP wells (Mann Whitney U-Test, BP p = 0.097, FPDc p = 0.77).