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. 2019 Aug 9;10:666. doi: 10.3389/fgene.2019.00666

Figure 3.

Figure 3

L-methionine effect on eclosion rate and body burden with MeHg exposure. (A) L-methionine and MeHg-cysteine conjugate are both substrates for the large amino acid transporter (LAT) (Aschner and Clarkson, 1989). L-methionine can act as a competitive inhibitor of MeHg uptake. (B, C) Eclosion rates of Canton S (CS) and Hikone R (HR) strains were determined after exposure to MeHg food with or without 5 mM L-methionine throughout larval stages (*p = <0.01, **p = <0.001, z-test). (D) Total Hg was determined in CS and HR early stage pupae (12–24 h APF) after exposure to the indicated concentration of MeHg in the presence or absence of 5 mM L-methionine throughout the larval stages (n = 3 replicates of pooled samples of 10 pupae; t-test; *p = <0.05, **p = <0.005 relative to CS; # p < 0.05, ## p < 0.005 relative to HR).