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. 2019 Aug 9;10:880. doi: 10.3389/fphar.2019.00880

Figure 1.

Figure 1

Development and progression of tubulointerstitial fibrosis and inflammation following folic acid (FA)–induced acute kidney failure. (A) Masson trichrome staining showing histological changes in the kidneys 2 days, 6 days, 2 weeks, and 4 weeks after folic acid or buffer injection. (B) Confocal microscopy showing expression of α-SMA, fibronectin (FN), and collagen IV (Col. IV) and (E) CD11b in the kidneys 2 days, 6 days, 2 weeks, and 4 weeks after folic acid or buffer injection. (C) Quantification of α-SMA, FN, and Col. IV staining area in the kidneys 2 days, 6 days, 2 weeks, and 4 weeks after folic acid or buffer injection. (D) Time course of serum cystatin c changes from mice after folic acid or buffer injection. (E) Confocal microscopy showing expression of CD11b after folic acid or buffer injection. Original magnification; ×400 (A and E); ×600 (B). Data are mean ± SD (n = 6/group). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.