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The impact of blockade of JNK and/or Smad3 signaling on folic acid (FA)–induced kidney injury. (A and B) Western blotting shows p-c-Jun, p-Smad3, and α-tubulin in kidneys from buffer-treated kidneys and FA-induced kidney disease treated with vehicle, SP600125, SIS3, or SP600125 + SIS3. (B) Quantification of Western blot results. *P < 0.05 vs. FA+vehicle-treated group;# P < 0.05 vs. FA+SIS3-treated group; $ P < 0.05 vs. FA+SP-treated group.
