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. 2019 Aug 9;10:888. doi: 10.3389/fphar.2019.00888

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Copyright © 2019 Cannavo, Marzano, Elia, Liccardo, Bencivenga, Gambino, Perna, Rapacciuolo, Cittadini, Ferrara, Paolocci, Koch and Rengo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aldosterone/mineralocorticoid receptor (MR) blockade prevents GRK2 upregulation in postischemic failing hearts and abolishes Insulin and βAR signaling downregulation. (A–C) Representative immunoblots (upper panels) and quantitative data (lower panels) showing levels of GRK2 (A), ^ser307pIRS1 (B) and β1AR (C) in total cardiac lysates of Sham, MI, and MI + Spiro mice (n = 3–6 mice per group). tIRS1 and GAPDH levels were used as loading control; Tukey’s post hoc test. *p < 0.05 versus Sham.