Table 2.

Aprepitant drug-drug interactions and adverse effects for some commonly co-administered drugs

Significant pharmacokinetic drug interactions with aprepitant/fosaprepitant reported	• Bosutinib PO • Cabazitaxel IV • Cyclophosphamide IV • Dexamethasone PO • Methylprednisolone IV • Midazolam PO/IV • Oxycodone PO • Tolbutamide PO
Possible adverse events resulting from an interaction with aprepitant/fosaprepitant	• Alcohol (impaired cognition) • Anthracyclines (infusion via the same peripheral vein may cause a local reaction at infusion site) • Ifosfamide (neurotoxicity) • Oxycodone (increased feeling of a “high,” decreased respiratory rate) • Quetiapine (somnolence) • Selective serotonin reuptake inhibitors/serotonin-norepinephrine reuptake inhibitors (vomiting) • Warfarin (INR changes)