Table 1.
List of molecular functions from ‘PANTHER-GO molecular functions’ which had increased more than 5-fold in expression during AKI.
| PANTHER GO-Slim Molecular Function and their GO number | AKI fold Enrichment | Raw P-value |
|---|---|---|
| Guanylate cyclase activity (GO:0004383) | 13.31 | 5.69E-04 |
| Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0004879) | 11.95 | 2.38E-10 |
| Tumor necrosis factor receptor binding (GO:0005164) | 11.09 | 4.47E-03 |
| Transmembrane receptor protein tyrosine kinase activity (GO:0004714) | 9.02 | 3.98E-10 |
| Peroxidase activity (GO:0004601) | 8.96 | 3.84E-05 |
| Chemokine activity (GO:0008009) | 8.63 | 4.72E-05 |
| Antioxidant activity (GO:0016209) | 8.32 | 5.02E-06 |
| Cytokine receptor activity (GO:0004896) | 7.04 | 1.86E-06 |
| Growth factor activity (GO:0008083) | 6.52 | 9.84E-06 |
| Phosphoric diester hydrolase activity (GO:0008081) | 5.55 | 1.40E-05 |
| RNA polymerase II transcription factor binding transcription factor activity (GO:0001076) | 5.23 | 2.28E-05 |