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. 2019 Aug 15;9:11937. doi: 10.1038/s41598-019-48422-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Circos representation of the total cytosine methylation intensities of the plus and minus strands of mitochondrial DNA in (A) oocytes, (B) blastocysts and (C) granulosa cells. The outer ring indicates the nucleotide position, while the inner ring shows the genes that encode proteins, tRNAs or rRNAs. (A) The red ring corresponds to DNA methylation in GVO from abattoir ovaries, while the green ring represents DNA methylation in OS/OPU GVOs. (B) The red ring depicts DNA methylation in blastocysts in vitro produced from GVOs from abattoir ovaries, while the green ring shows DNA methylation in blastocysts in vitro produced from OS/OPU GVOs. (C) The red ring corresponds to DNA methylation in granulosa cells from adult cows, while the green ring represents DNA methylation in granulosa from pre-pubertal cows.