Fig. 4.

Changes in transcription related factors. Protein levels of total CREB (A); phospho-CREB (B); ratio of phospho- to total CREB (C); PGC-1α (D); c-FOS (E); and c-MYC (F) are shown. The protein levels of these components were determined by Western blotting. As in Fig. 2, values are fold change over respective sex controls and are mean ± S.E.M. (n = 4 rats). a, Significant compared with control (P < 0.05); b, significant compared with the male ethanol binge group; (P < 0.05). FC, female control; FE, female ethanol binge; MC, male control; ME, male ethanol binge.