Table 3. . Urinary acetylamantadine concentration in healthy adult volunteers recruited locally at Dhaka (Bangladesh site).
| Subject ID | 2 h [AA] (ng/ml) | Urine (ml) | Total AA (ng) | 4 h [AA] (ng/ml) | Urine (ml) | Total AA (ng) | 6 h [AA] (ng/ml) | Urine (ml) | Total AA (ng) |
|---|---|---|---|---|---|---|---|---|---|
| H01† | 25.4 | 70 | 1778 | 24.4 | 85 | 2074 | 58.2 | 20 | 1164 |
| H02 | 20.1 | 110 | 2211 | 10.8 | 120 | 1296 | 16.9 | 115 | 1944 |
| H03† | 11.9 | 100 | 1190 | 165 | 100 | 16,500 | 156 | 55 | 8580 |
| H04† | 6.0 | 80 | 478 | 65.3 | 80 | 5224 | 32.1 | 85 | 2729 |
| H05† | 49.5 | 90 | 4455 | 83.3 | 85 | 7081 | 178 | 55 | 9790 |
| H06† | 10.5 | 90 | 945 | 26.2 | 70 | 1834 | 83.2 | 65 | 5408 |
| H07† | 11.0 | 85 | 935 | 29.1 | 90 | 2619 | 66.4 | 60 | 3984 |
| H08† | 24.7 | 55 | 1359 | 37.6 | 80 | 3008 | 34.3 | 90 | 3087 |
| H09† | 42.0 | 100 | 4200 | 42.0 | 70 | 2940 | 40.6 | 100 | 4060 |
| H10† | 11.6 | 75 | 870 | 43.3 | 60 | 2598 | 156 | 50 | 7800 |
| H11† | 3.0 | 130 | 384 | 185 | 35 | 6475 | 45.1 | 60 | 2706 |
| H12† | 31.4 | 70 | 2198 | 132 | 60 | 7920 | 91.3 | 80 | 7304 |
| H13† | 6.4 | 70 | 446 | 53.1 | 65 | 3452 | 113 | 60 | 6780 |
| H14 | 21.1 | 80 | 1688 | 19.4 | 100 | 1940 | 19.4 | 75 | 1455 |
| H15 | 7.7 | 90 | 697 | 10.5 | 70 | 735 | 16.2 | 75 | 1215 |
| H16 | 14.6 | 95 | 1387 | 24.7 | 80 | 1976 | 9.4 | 65 | 614 |
| H17† | 9.8 | 100 | 984 | 60.8 | 100 | 6080 | 27.3 | 90 | 2457 |
| H18† | 22.8 | 100 | 2280 | 28.2 | 90 | 2538 | 25.1 | 90 | 2259 |
| H19 | 5.2 | 120 | 623 | 18.0 | 100 | 1800 | 8.1 | 90 | 725 |
| H20 | 14.9 | 90 | 1341 | 24.0 | 110 | 2640 | 8.0 | 120 | 959 |
| H21 | 9.0 | 75 | 677 | 10.2 | 80 | 816 | 4.7 | 80 | 378 |
| H22 | 6.8 | 60 | 408 | 30.9 | 95 | 2934 | 5.2 | 90 | 466 |
| H23 | 4.3 | 60 | 256 | 7.1 | 60 | 425 | 3.6 | 80 | 284 |
| H24 | 7.5 | 65 | 488 | 14.3 | 100 | 1430 | 9.6 | 75 | 722 |
| H25 | 12.8 | 45 | 576 | 11.6 | 40 | 464 | 2.8 | 110 | 306 |
| H26† | 63.3 | 90 | 5697 | 35.8 | 75 | 2685 | 10.5 | 200 | 2100 |
| H27 | 21.5 | 90 | 1935 | 30.7 | 50 | 1535 | 22.6 | 55 | 1243 |
| H28 | 3.2 | 80 | 254 | 80.6 | 60 | 484 | 12.6 | 115 | 1449 |
| H29 | 1.5 | 110 | 164 | 6.1 | 110 | 673 | 13.7 | 105 | 1439 |
| H30† | 2.9 | 70 | 204 | 13.8 | 55 | 759 | 96 | 30 | 2880 |
| H31† | 3.5 | 120 | 414 | 14.7 | 70 | 1029 | 34.6 | 70 | 2422 |
| H32† | 18.0 | 100 | 1800 | 14.5 | 90 | 1305 | 42.5 | 70 | 2975 |
| H33† | 6.3 | 100 | 626 | 34.6 | 70 | 2422 | 52.6 | 80 | 4208 |
| H34 | 47.2 | 100 | 4720 | 2.8 | 80 | 227 | 7.2 | 75 | 542 |
| H35 | 11.3 | 110 | 1243 | 13.9 | 110 | 1529 | 13.5 | 100 | 1350 |
| H36 | 23.1 | 100 | 2310 | 26.7 | 105 | 2804 | 11.5 | 100 | 1150 |
| H37 | 7.7 | 80 | 617 | 13.7 | 100 | 1370 | 15.2 | 90 | 1368 |
| H38 | 1.6 | 80 | 127 | 8.1 | 75 | 609 | 5.6 | 95 | 535 |
| H39† | 22.0 | 80 | 1760 | 24.2 | 100 | 2420 | 24.0 | 95 | 2280 |
| H40 | 7.4 | 105 | 781 | 19.2 | 85 | 1632 | 11.20 | 85 | 286 |
†
Identified as an outlier based on total AA amount (ng) at 6 h time point of >2000 ng or concentration of AA >24.0 ng/ml.
AA: Acetylamantadine.