Table 7. . Urinary acetylamantadine concentration in healthy adult volunteers recruited locally at Asper Clinical Research Institute (Winnipeg site).
Subject ID | 2 h [AA] (ng/ml) | Urine (ml) | Total AA (ng) | 4 h [AA] (ng/ml) | Urine (ml) | Total AA (ng) | 6 h [AA] (ng/ml) | Urine (ml) | Total AA (ng) |
---|---|---|---|---|---|---|---|---|---|
BM0001 | 2.0 | 220 | 429 | 2.2 | 205 | 445 | 3.5 | 130 | 452 |
BM0002† | 10.5 | 20 | 210 | 10.6 | 40 | 424 | 10.7 | 75 | 803 |
BM0003† | 1.7 | 180 | 297 | 3.4 | 238 | 809 | 1.4 | 228 | 309 |
BM0004† | 1.1 | 410 | 442 | 2.8 | 320 | 880 | 4.5 | 130 | 589 |
BM0005† | 3.8 | 40 | 152 | 3.2 | 190 | 614 | 1.4 | 180 | 252 |
BM0006† | 1.2 | 85 | 99 | 8.7 | 145 | 1260 | 2.0 | 165 | 333 |
BM0007† | 3.0 | 165 | 501 | 14.9 | 120 | 1788 | 4.0 | 175 | 707 |
BM0008 | 1.6 | 190 | 296 | 1.7 | 205 | 344 | 5.0 | 170 | 841 |
BM0009† | 3.9 | 170 | 660 | 9.2 | 130 | 1191 | 5.8 | 210 | 1210 |
BM0010 | 1.1 | 7 | 8 | 0.8 | 120 | 99 | 0.4 | 100 | 42 |
BM0011† | 0.8 | 410 | 314 | 3.2 | 400 | 1288 | 1.7 | 390 | 655 |
BM0021† | 2.7 | 220 | 603 | 9.3 | 460 | 4264 | 5.3 | 190 | 1005 |
BM0022 | 2.3 | 90 | 207 | 2.0 | 95 | 194 | 2.1 | 100 | 211 |
BM0023 | 0.6 | 315 | 201 | 3.3 | 85 | 282 | 2.4 | 155 | 369 |
BM0024 | 4.4 | 55 | 239 | 4.6 | 90 | 413 | 4.4 | 130 | 569 |
BM0025 | 1.4 | 50 | 69 | 4.0 | 50 | 198 | 2.3 | 100 | 229 |
BM0026† | 0.6 | 245 | 142 | 2.6 | 305 | 790 | 3.5 | 75 | 264 |
BM0027 | 5.2 | 160 | 837 | 4.4 | 80 | 353 | 4.6 | 130 | 593 |
BM0028† | 3.8 | 220 | 834 | 10.7 | 100 | 1070 | 14.8 | 115 | 1702 |
BM0029 | 4.6 | 120 | 550 | 5.8 | 100 | 575 | 4.5 | 140 | 631 |
Identified as an outlier based on total AA amount (ng) at 4 h time point of more than 600 ng or concentration of AA more than 6.0 ng/ml.
AA: Acetylamantadine.