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. 2019 Aug 9;10:1006. doi: 10.3389/fphys.2019.01006

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Copyright © 2019 Han, Zhou, Coetzee and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the target substrates of SIRT4, SIRT1, and SIRT3 involved in fatty acid oxidation. SIRT4 directly (pink ovals) or indirectly (yellow rectangles) modulates the activity of various target substrates involved in fatty acid metabolism. ACC, acetyl CoA carboxylase; CPT1, carnitine palmitoyltransferase 1; FAO, fatty acid oxidation.