Table 2.
Comparison of different methods used for the detection of difenidol hydrochloride.
| Methods | Linear Range (mol·L−1) | Detection Limit (mol·L−1) | References |
|---|---|---|---|
| HPLC | 3.58 × 10−5–1.08 × 10−4 | — | [5] |
| LC-MS/MS | 2.89 × 10−9–2.89 × 10−7 | 1.45 × 10−9 | [7] |
| Post-chemiluminescence | 1.73 × 10−8–2.89 × 10−7 | 5.78 × 10−9 | [8] |
| CE-ECL | 1.00 × 10−6–6.00 × 10−5 | 1.00 × 10−7 | [29] |
| ECL | 1.00 × 10−6–3.30 × 10−5 | 5.00 × 10−7 | [30] |
| ECL | 1.00 × 10−7–1.00 × 10−4 | 6.49 × 10−10 | [42] |
| ECL | 3.00 × 10−8–2.00 × 10−5 | 8.64 × 10−10 | This work |
HPLC: high-performance liquid chromatography, LC-MS/MS: liquid chromatography-mass spectrometry, CE: capillary electrophoresis.