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. 2019 Jul 30;20(15):3727. doi: 10.3390/ijms20153727

Figure 7.

Figure 7

Interaction between chronic administration of cytokines and CGS21680 on basal, AdA-, and AMPA-evoked releases of L-glutamate. Interaction between effects of chronic administration of IFNγ (100 IU/mL), TNFα (100 IU/mL), and CGS21680 (CGS: 10 nM) on basal (opened) and 1 μM AdA-evoked (A, blue) L-glutamate release are indicated in Figure 7A. Interaction between effects of chronic administration of IFNγ (100 IU/mL), TNFα (100 IU/mL), and CGS21680 (10 nM) on basal (opened) and 100 μM AMPA-evoked (B, red) L-glutamate release are indicated in Figure 7B. Ordinates indicate mean levels of L-glutamate (μM) (N = 6). * p < 0.05 relative to non-CGS and # p < 0.05 relative to control by two-way ANOVA with Tukey’s post hoc test.