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. 2019 Jul 30;20(15):3727. doi: 10.3390/ijms20153727

Figure 8.

Figure 8

Interaction between chronic administration of cytokines, sub-effective concentration of CGS21680 (10 nM), and therapeutic-relevant concentration of CBZ (20 μM) on 100 nM CGS21680-evoked L-glutamate release. Effects of chronic administration of IFNγ (100 IU/mL), TNFα (100 IU/mL), and CGS (10 nM) on basal (opened) and 100 nM CGS-evoked (closed) releases of L-glutamate from cultured astrocytes are indicated in Figure 8A. Effects of chronic administration of IFNγ (100 IU/mL), TNFα (100 IU/mL), and CBZ (20 μM) on basal (opened) and 100 nM CGS-evoked (closed) releases of L-glutamate from cultured astrocytes are indicated in Figure 8B. Ordinates indicate mean levels of L-glutamate (μM) (N = 6). * p < 0.05 relative to non-CGS (A) or non-CBZ (B) and # p < 0.05 relative to control by two-way ANOVA with Tukey’s post hoc test.