Table 2.

Effects of CBZ and CGS21680 on Astroglial L-Glutamate Release after Chronic Cytokine Administration.

	After Chronic IFNγ Administraion				After Chronic TNFα Administraion
	Basal	AdA-Evoke	AMPA-Evoke	CGS-Evoke	Basal	AdA-Evoke	AMPA-Evoke	CGS-Evoke
CBZ (Acute)	→	↓	↓		↓	↓	↓
CBZ (chronic)	→	↓	↓	↑	↓	↓	↓	↓
CGS (Chronic)	→	↓	→	↑	↓	↓	↓	↓

Effects of acute and chronic administrations of therapeutic-relevant concentration of CBZ (20 μM) and sub-effective concentration of CGS21680 (10 nM) on basal, 1 μM AdA-evoked, 100 μM AMPA-evoked, and 100 nM CGS21680-evoked astroglial L-glutamate releases after the chronic administration of 100 IU/mL IFNγ (left) and TNFα (right) are indicated in Table 2. →: Did not affect, ↑: Increased, and ↓: Decreased astroglial L-glutamate release.