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. 2019 Aug 6;20(15):3843. doi: 10.3390/ijms20153843

Figure 5.

Figure 5

Olmesartan suppresses apoptosis and inflammation in the kidney of Col4a3–/– mice. (a) Comparison of protein expression level for molecules related to apoptosis determined by immunoblotting from the kidney of WT, Col4a3–/–, and Col4a3-/-+Olm mice (n = 4 mice/group). β-actin was used as the endogenous control. (b) Representative images of TUNEL (upper) and immunohistochemical staining for F4/80 (lower) in the kidney of WT, Col4a3–/–, and Col4a3-/-+Olm mice. (c) Comparison of mRNA expression level for inflammatory markers determined by qPRC from the kidney of WT, Col4a3–/–, and Col4a3-/-+Olm mice (n = 4 mice/group). β-actin was used as the endogenous control. (d) Comparison of protein expression level for CD68 and hemoxygenase-1 (HO-1) determined by immunoblotting from the kidney of WT, Col4a3–/–, and Col4a3-/-+Olm mice (n = 4 mice/group). β-actin was used as the endogenous control. Scale bars, 50 μm. * P < 0.05, ** P < 0.01 versus WT mice; # P < 0.05, ## P < 0.01 versus Col4a3–/– mice by one-way ANOVA with Newman–Keuls multiple comparison test.