Table 1.
Effect of Olmesartan on the renal function in Col4a3–/– mice.
| WT | Col4a3–/– | Col4a3-/-+Olm | |
|---|---|---|---|
| Body weight (g) | 19.7 ± 2.6 | 20.0 ± 0.4 | 20.7 ± 1.0 |
| Kidney weight (g) | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 |
| Kidney weight / body weight (g/kg) | 7.6 ± 1.6 | 9.3 ± 0.3 | 8.3 ± 0.4 |
| Urine creatinine (mg/dL) | 49.0 ± 10.5 | 21.2 ± 3.5 * | 9.1 ± 3.3 ## |
| Urine albumin (μg/mL) | 7.2 ± 2.0 | 234.5 ± 32.5 * | 72.0 ± 45.1 # |
| Urine albumin-to-creatinine ratio | 15.1 ± 4.4 | 1119.0 ± 188.5 ** | 426.3 ± 105.1 **,## |
| Serum NGAL (ng/mL) | 77.2 ± 7.5 | 335.5 ± 126.1 * | 43.8 ± 6.4 # |
| Urine NGAL (ng/mL) | 61.1 ± 3.8 | 848.8 ± 12.7 ** | 27.8 ± 2.8 ## |
Values are expressed as mean ± SE. NGAL, neutrophil gelatinase-associated lipocalin. * P < 0.05, ** P < 0.01 versus WT mice; # P < 0.05, ## P < 0.01 versus Col4a3–/– mice by one-way ANOVA with Newman–Keuls multiple comparison test.