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. 2019 Jul 25;20(15):3644. doi: 10.3390/ijms20153644

Figure 1.

Figure 1

Particle analysis of N-IMC and N-IMC/MT gels immediately after the bead mill treatment. (A) and (B); the particle size frequencies in transdermal formulations containing indomethacin (IMC) powder (P-IMC, A) and transdermal formulations containing IMC powder and l-menthol (P-IMC/MT, B) gels by SALD-7100. (C and D); the particle size frequencies of N-IMC (C) and N-IMC/MT (D) gels by SALD-7100. (E and F); the particle size frequencies of N-IMC (E) and N-IMC/MT (F) gels by NANOSIGHT LM10. (G and H); atomic force microscope (AFM) images of N-IMC (G) and N-IMC/MT (H) gels by SPM-9700. The particle size of IMC was decreased to approximately 50–200 nm, and no differences were observed in the particle characterizations between the N-IMC and N-IMC/MT gels.