AFM |
atomic force microscope |
AUC
|
area under the indomethacin concentration-time curve |
carbopol |
Carbopol® 934 |
COX |
cyclooxygenase |
D
|
diffusion constant within the skin |
HPβCD |
2-hydroxypropyl-β-cyclodextrin |
IMC |
indomethacin |
P-IMC gel |
transdermal formulations containing indomethacin solid microparticles |
N-IMC gel |
transdermal formulations containing indomethacin solid nanoparticles |
J
c
|
penetration rate |
k
a
|
apparent absorption rate constant |
k
e
|
elimination rate constant |
K
m
|
skin/preparation partition coefficient |
K
p
|
penetration coefficient through the skin |
k
r
|
drug release rate constant |
MC |
methylcellulose |
P-IMC/MT gel |
transdermal formulations containing indomethacin solid microparticles and l-menthol |
N-IMC/MT gel |
transdermal formulations containing indomethacin solid nanoparticles and l-menthol |
NSAIDs |
non-steroidal anti-inflammatory drug |
SC |
stratum corneum |
SNPs |
solid nanoparticles |
TDD |
transdermal drug delivery |
t
lag
|
lag time |
XRD |
powder X-ray diffraction |