Table 1.
Genome-wide association studies (GWAS) in AD.
| Study | Ethnic Group | Sample Size | Locus | SNPs |
|---|---|---|---|---|
| [17] | African-American/ Afro-Caribbean |
AD cases: 1009; Control: 6205 | CLU PICALM CR1 BIN1 CD2AP EPHA1 MS4A ABCA7 |
rs2279590 rs3851179 rs6656401 rs744373 rs9349407 rs11767557 rs4938933 rs3865444 |
| [18] | European ancestry, African-American, Japanese, Israeli-Arabic |
Stage 1: European ancestry: AD cases: 13,100; control: 13,220 African-American: AD cases: 1472; control: 3511 Japanese: AD cases: 951; control: 894 Israeli Arab: AD cases: 51; control: 64 Stage 2: European ancestry: AD cases: 5813; control: 20,474 |
PFDN1/HBEGF USP6NL/ECHDC3 BZRAP1-AS1 NFIC |
rs1116803 rs7920721 rs2632516 rs9749589 |
| [19] | European | Stage 1: AD cases: 3957; control 9682 Stage 2: AD cases: 2023; control: 2340 |
TOMM40 PVRL2 APOE CLU PICALM |
rs2075650 rs157580 rs6859 rs8106922 rs405509 rs11136000 rs3851179 |
| [20] | European African unspecified NR |
European: 16,063 African: 2329 other: 673 |
TOMM40 APOE PVRL2 APOC1 |
rs2075650 rs405509 rs8106922 rs6859 rs20769449 rs12721046 rs157582 rs71352238 rs157580 rs439401 rs115881343 rs76366238 rs283815 |
| [21] | Caribbean Hispanic | AD cases: 2451; control: 2063 | TOMM40–APOE region FBXL7 CACNA2D |
rs394819 rs7500204 Rs743199 |
| [22] | European | AD Cases: 71,880; control 383,378 | ADAMTS4 HESX1 CLNK CNTNAP2 ADAM10 APH1B KAT8 ALPK2 AC074212.3 |
rs4575098 rs184384746 rs114360492 rs442495 rs117618017 rs59735493 rs76726049 rs76320948 |
| [23] | African-Americans | AD cases: 1825; control: 3784 | COBL SLC10A2 |
rs112404845 rs16961023 |
| [24] | African-Americans | AD cases: 1968; control: 3928 | ABCA7 HMHA1 GRIN3B |
rs115550680 rs115553053 rs115882880 rs145848414 |