Table 1.
In situ ATH of different cyclic imines with the [Ir(Cp*)(Van)Cl] complex.
| Entry | Buffer | Sub 1 Conv. % (e.e.%) |
Sub 2 Conv. % (e.e.%) |
Sub3 Conv. % (e.e.%) |
|---|---|---|---|---|
| 1 | Phosphate 0.1 M pH 8 |
56 (20, R) (a) | 30 (36, R) | 92 (42, R) |
| 2 | MOPS 1.2 M pH 7.8 |
34 (rac) | 40 (46, R) | 64 (rac) |
| 3 | MES 1.2 M pH 7 |
82 (4, S) | 30 (9, R) | 60 (4, R) |
| 4 | MES 1.2 M pH 6 |
40 (4, S) | 67 (12, R) | 25 (rac) |
| 5 | Acetate 0.1 M pH 5 |
34 (3, S) | 20 (21, R) | 30 (rac) |
| 6 | MES 1.2 M pH 5 |
75 (5, S) | 35 (61, R) | 20 (30, S) |
Reaction conditions: substrate concentration 16 mM, 4 mol% Van, 1 mol% [IrCp*Cl2]2, buffer, HCOONa 3 M, 18 h and at 25 °C. (a) substrate 16 mM, 8 mol% Van, 1 mol% [IrCp*Cl2]2, buffer, HCOONa 3 M, 18 h and at 25 °C.