Figure 1.

Schematic illustration of the molecular charge contact (MCC)-based ISFET sensor. (a) Basic structure of electrical measurement using the MCC-based ISFET sensor. Biomolecular recognition events such as an antigen—antibody reaction occur on magnetic beads but not at the gate insulator of the ISFET. Magnetic beads with biomolecules are made to approach the gate insulator using a button magnet from below the ISFET substrate; (b) the previously reported MCC method; and (c) the improved MCC method in this study.