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. 2019 Aug 5;20(15):3832. doi: 10.3390/ijms20153832

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The roles of endocytic proteins in the delivery of 1α,25(OH)₂D in the renal cells. The majority of the circulating 25-hydroxyvitamin D is bound to DBP, which is endocytosed via megalin and cubulin-mediated endocytosis. DBP is degraded, and 25(OH)D is either converted to 1α,25(OH)₂D in the mitochondria for CYP27B1-mediated bioactivation or is secreted into circulation where it binds to DBP by CYP24A1-mediated inactivation. Cubilin and megalin then return back to the cell surface and the process gets repeated.