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Summary of reaction scheme to yield UA analogues (78–106). Reagents and conditions: (a) Jones reagent, acetone at 0 °C for 5 h; (b) ethanol, substituted oaminobenzaldehyde, potassium hydroxide (KOH), reflux under N2 atmospheric conditions for 24 h; (c) Thionyl chloride (SOCl2), benzene, reflux for 3 h; RCONHNH2, trimethylamine (Et3N), dichloromethane (CH2Cl2)/ether at room temperature for 8–12 h; (d) p-Toluenesulfonic acid (TsOH), toluene, reflux for 6 h.
