Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 30;20(15):3715. doi: 10.3390/ijms20153715

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Viruses differently modulate the expression of DNAM-1 and their ligands depending on the infection phase. The viruses mentioned in this review (CMV, HIV-1, HSV, EBV, and HCV) differently express proteins associated with the various viral infection phases. Viral proteins (blue boxes) can upregulate (green arrow) or downregulate (red inhibition symbol) the expression of DNAM-1 and its ligands, such as PVR and Nectin-2, as reported in the legend. The US2 protein of CMV supports the immunomodulating function of UL141 during viral infection (blue arrow). References relative to each mechanism are reported in parenthesis. General missing information are indicated by emoticons, while missing information on viral molecules are indicated by question marks.