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An example of a collagen peptide and its hydration shell: (a) in conventional science, biomolecules are usually represented only by this main chain on a black background, as if the biomolecular processes are happening in the vacuum; (b–d), a realistic picture, showing water hydration shells as an integral part [57] (Reprinted from Bella J, Brodsky B, Berman HM. Hydration structure of a collagen peptide. Structure 1995; 3:893–906, with permission from Elsevier).
