Table 1.
Changes in the expression of cytokines, chemokines, and receptors in the lesional epidermis of several hyperpigmentary disorders when compared with non-lesional skin [8,25,30].
|
→Epidermis →Dermis |
Cytokine/Chemokine | Receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ET-1 | SCF | GROa | HGF | bFGF | KGF | IL-1a | TNFa | EDNBR | c-KIT | KGFR | |
| UVB melanosis | ↑ | ↑ | → | → | ↑ | ↑ | ↑ | → | ↑ | → | ↑ |
| Solar Lentigo | ↑ | ↑ | → | ? | → | ↑ | ↓ | ↑ | ↑ | ↗ | ↑ |
| Seborrehoic Keratosis | ↑ | ⇡ | ? | ? | ? | ? | ↓ | ↑ | ? | ? | ? |
| Dermato-fibroma |
→
→ |
↑
→ |
→
→ |
↑
→ |
→
→ |
? | ? | ? | ? | ↑ | ? |
|
Café-au-lait
macules |
→
→ |
↑ | ? | ↑ | → | ? | ? | ? | ? | ? | ? |
| Riehl’s Melanosis | ? | ? | ↑ | ? | ? | ? | ↑ | ? | ? | ? | ? |
| Vitiligo Vulgaris | ↑ | ↑ | ? | → | → | ? | ? | ? | → | ↓ | ? |