Table 3.

Types of interactions between CDDP and SAHA or VPA at the fixed-ratio combination of 1:1 in MDA-MB-231 cancer cell lines with increased (Notch1^highMDA-MB-231) or decreased (Notch1^lowMDA-MB-231) activity of Notch1 with reference to MDA-MB-231 breast cancer cells with native level of Notch1 activity (MDA-MB-231^native) [28] measured in vitro by the MTT assay.

Combination	Notch1highMDA-MB-231	Notch1lowMDA-MB-231	MDA-MB-231native [28]
CDDP/VPA	additivity	additivity	antagonism
CDDP/SAHA	additivity	additivity with tendency towards antagonism	additivity