Soy isoflavones reduce body weight and the serum triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL) concentrations. (A) The body weight of rats fed a basal diet and the high-fat diet for nine weeks; (B) the plasma TG, TC, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) concentrations of rats fed a basal diet and high-fat diet; (C) the body weight trend of rats in the control, obesity control group (OB), low dose of isoflavones (LSI), middle dose of isoflavones (MSI), and high dose of isoflavones (HSI) groups. a**: b vs. a, p < 0.01; d*: b vs. d, p < 0.05; e*: b vs. e, p < 0.05; e**: b vs. e, p < 0.01; (D) the plasma TG, TC, HDL, and LDL concentration of rats in each group at the thirteenth week; and (E) feed intake of rats in each group during the intervention of soy isoflavones. Error bars indicate SEM. * p < 0.05, ** p < 0.01. ns, no statistical significance. a control group, b obesity group, c low-dose soy isoflavones group, d middle-dose soy isoflavones group, e high-dose soy isoflavones group.