Table 3.
Hypergeometric analyses of case-control associated genes and SFARI genes.
| Case Groups (Combined Q1 and Q4) vs. Unaffected Controls | Number of Case-Associated Genes | # Genes Represented within SFARI Gene | Q-Value * for Enrichment |
|---|---|---|---|
| dA.MZ | 13 | 0 | 1 |
| dA.DZ | 8 | 0 | 1 |
| dNA.MZ | 53 | 9 | 1.69 × 10−3 |
| dNA.DZ | 19 | 4 | 1.59 × 10−2 |
| cMZ | 29 | 2 | 4.58 × 10−1 |
| cDZ | 23 | 4 | 3.10 × 10−2 |
* For the hypergeometric distribution analyses, the total number of genes in the population was estimated to be 20,406; and the total number of ASD-associated genes in the SFARI gene database was 1079.