Table 4.
Neurological functions associated with genes implicated by language QTNs.
| Functions Annotation | p-Value * | Genes |
|---|---|---|
| cell-cell adhesion of neurons | 9.52 × 10−6 | CDK5R1, CNTN4, NRXN1 |
| guidance of axons | 9.66 × 10−6 | CDK5R1, CNTN1, CNTN4, LHX4, NRXN1, UNC5D |
| fasciculation of axons | 8.24 × 10−5 | CDK5R1, CNTN1, CNTN4 |
| abnormal morphology of brain | 1.86 × 10−4 | CDK5R1, CHRM1, CHRNA7, CNTN1, ID3, LHX4, NPAS3, TOP2B |
| GABA-mediated receptor currents | 6.98 × 10−4 | CHRNA7, NRXN1 |
| abnormal morphology of granule cells | 9.17 × 10−4 | CDK5R1, CNTN1 |
| abnormal morphology of nervous system | 1.48 × 10−3 | CDK5R1, CHRM1, CHRNA7, CNTN1, CNTN4, ID3, LHX4, NPAS3, TOP2B |
| stratification of cerebral cortex | 1.75 × 10−3 | CDK5R1, TOP2B |
| formation of brain | 2.52 × 10−3 | BMP5, CDK5R1, CNTN1, CREM, DSCAML1, NPAS3, TOP2B |
| memory | 2.58 × 10−3 | CDK5R1, CHRM1, CHRNA7, CREM, NPAS3 |
| abnormal morphology of molecular layer of cerebellum | 2.63 × 10−3 | CDK5R1, CNTN1 |
| formation of enteric ganglion | 2.82 × 10−3 | PAX3 |
| morphology of motor cortex | 2.82 × 10−3 | CDK5R1 |
| origination of axons | 2.82 × 10−3 | CDK5R1 |
| reorganization of molecular layer | 2.82 × 10−3 | CDK5R1 |
| sprouting of mossy fiber cells | 2.82 × 10−3 | CDK5R1 |
* Fisher exact p-value which indicates the probability that the list of SNP-associated genes is not enriched for annotated function, using genes in IPA’s Knowledgebase as the reference set of genes.