Table 5.
Neurological functions associated with genes implicated by nonverbal QTNs.
| Functions Annotation | p-Value * | Genes |
|---|---|---|
| organization of mossy fibers | 2.60 × 10−3 | CHL1 |
| formation of enteric ganglion | 2.60 × 10−3 | PAX3 |
| targeting of retinal ganglion cells | 2.60 × 10−3 | EPHB1 |
| cell-cell adhesion of astrocytes | 2.60 × 10−3 | CADM1 |
| maintenance of neural crest | 5.18 × 10−3 | PAX3 |
| survival of neural crest | 5.18 × 10−3 | PAX3 |
| innervation of forelimb | 7.77 × 10−3 | BMPR2 |
| differentiation of satellite cells | 1.03 × 10−2 | PAX3 |
| morphogenesis of optic nerve | 1.29 × 10−2 | EPHB1 |
| migration of pyramidal neurons | 1.29 × 10−2 | CHL1 |
| abnormal pruning of axons | 1.29 × 10−2 | EPHB1 |
| excitatory postsynaptic potential of neurons | 1.39 × 10−2 | DLG2, RARB |
| formation of pyramidal neurons | 1.55 × 10−2 | CHL1 |
| synaptic depression of collateral synapses | 1.80 × 10−2 | EPHB1 |
| synaptic transmission of collateral synapses | 1.80 × 10−2 | EPHB1 |
| abnormal morphology of axons | 2.29 × 10−2 | CHL1, EPHB1 |
| development of retinal pigment epithelium | 2.31 × 10−2 | RARB |
| abnormal morphology of optic tract | 2.31 × 10−2 | EPHB1 |
| abnormal morphology of hypoglossal nerve | 2.82 × 10−2 | RARB |
| abnormal morphology of olfactory receptor neurons | 3.32 × 10−2 | CHL1 |
| abnormal morphology of mossy fibers | 4.07 × 10−2 | CHL1 |
| projection of axons | 4.57 × 10−2 | CHL1 |
| synaptic transmission of nervous tissue | 4.74 × 10−2 | ANKS1B, EPHB1 |
| abnormal morphology of neural arch | 4.82 × 10−2 | RARB |
* Fisher exact p-value which indicates the probability that the list of SNP-associated genes is not enriched for annotated function, using genes in IPA’s Knowledgebase as the reference set of genes.