Table 6.
Neurological functions associated with genes implicated by play skills QTNs.
| Functions Annotation | p-Value * | Genes |
|---|---|---|
| formation of dendritic spines | 6.97 × 10−4 | ITSN1, KALRN |
| short-term depression of calyx-type synapse | 7.29 × 10−4 | ITSN1 |
| neurotransmission of synapse | 8.88 × 10−4 | CHRM3, PRKN |
| formation of tip of neurite-like extensions | 1.46 × 10−3 | KALRN |
| elongation of dendritic spine neck | 1.46 × 10−3 | ITSN1 |
| long-term potentiation of Purkinje cells | 1.46 × 10−3 | CHRM3 |
| arrest in axonal transport of mitochondria | 1.46 × 10−3 | PRKN |
| quantity of catecholaminergic neurons | 1.46 × 10−3 | PRKN |
| length of neurons | 2.18 × 10−3 | ITSN1, KALRN |
| excitation of striatal neurons | 2.18 × 10−3 | PRKN |
| differentiation of satellite cells | 2.91 × 10−3 | PAX7 |
| replenishment of synaptic vesicles | 2.91 × 10−3 | ITSN1 |
| abnormal morphology of locus ceruleus | 2.91 × 10−3 | PRKN |
| afterhyperpolarization of pyramidal neurons | 4.36 × 10−3 | CHRM3 |
| morphology of corticcal neurons | 4.36 × 10−3 | KALRN |
| sensorimotor integration | 5.09 × 10−3 | PRKN |
| abnormal morphology of substantia nigra | 5.81 × 10−3 | PRKN |
| neurotransmission | 6.89 × 10−3 | CHRM3,,KALRN, PRKN |
| morphogenesis of dendritic spines | 7.26 × 10−3 | KALRN |
| retraction of dendrites | 7.99 × 10−3 | KALRN |
| maturation of dendritic spines | 8.71 × 10−3 | KALRN |
| length of axons | 9.43 × 10−3 | KALRN |
| abnormal morphology of cerebral cortex | 9.91 × 10−3 | KALRN,,PRKN |
| length of dendritic spines | 1.38 × 10−2 | ITSN1 |
| coordination | 1.43 × 10−2 | KALRN, PRKN |
* Fisher exact p-value which indicates the probability that the list of SNP-associated genes is not enriched for annotated function, using genes in IPA’s Knowledgebase as the reference set of genes.