Table 8.
Neurological functions associated with genes implicated by Perseverative behavior QTNs.
| Diseases or Functions Annotation | p-value * | Genes |
|---|---|---|
| paired-pulse facilitation of parallel fiber-Purkinje cell synapses | 1.27 × 10−3 | UNC13C |
| early infantile epileptic encephalopathy type 12 | 1.27 × 10−3 | PLCB1 |
| loss of hippocampal neurons | 6.36 × 10−3 | PLCB1 |
| epilepsy | 1.27 × 10−2 | GABRR2, PLCB1, PRICKLE1 |
| afterhyperpolarization of neurons | 2.27 × 10−2 | KCNAB1 |
| progressive myoclonic epilepsy | 2.64 × 10−2 | PRICKLE1 |
| status epilepticus | 4.13 × 10−2 | GABRR2 |
| density of synapse | 4.61 × 10−2 | GRIP1 |
| sedation | 4.61 × 10−2 | GABRR2 |
* Fisher exact p-value which indicates the probability that the list of SNP-associated genes is not enriched for annotated function, using genes in IPA’s Knowledgebase as the reference set of genes.