Table 10.
Neurological functions implicated by QTN-associated genes in dNA.DZ.
| Diseases or Functions Annotation | p-Value * | Genes |
|---|---|---|
| adhesion of cerebellar granule cell | 8.65 × 10−4 | ADGRG1 |
| migration of CA1 neuron | 8.65 × 10−4 | DISC1 |
| abnormal morphology of lumbar dorsal root ganglion | 8.62 × 10−3 | GABBR1 |
| abnormal morphology of somatic nervous system | 1.03 × 10−2 | GABBR1 |
| pervasive developmental disorder | 1.44 × 10−2 | CORO2A, GABBR1 |
| abnormal morphology of sciatic nerve | 1.46 × 10−2 | GABBR1 |
| positioning of neurons | 1.55 × 10−2 | DISC1 |
| development of olfactory cilia | 1.80 × 10−2 | DISC1 |
| progressive myoclonic epilepsy | 1.80 × 10−2 | PRICKLE1 |
| maturation of synapse | 1.89 × 10−2 | DISC1 |
| migration of neuronal progenitor cells | 1.97 × 10−2 | ADGGRG1 |
| fragile X syndrome | 2.48 × 10−2 | GABBR1 |
| elongation of axons | 2.73 × 10−2 | DISC1 |
| migration of neurons | 2.81 × 10−2 | ADGRG1, DISC1 |
| abnormal morphology of myelin sheath | 2.99 × 10−2 | GABBR1 |
| differentiation of oligodendroccyte precursor cells | 3.24 × 10−2 | DISC1 |
| absense seizure | 3.24 × 10−2 | GABBR1 |
| passive avoidance learning | 3.49 × 10−2 | GABBR1 |
| inhibitory postsynaptic current | 4.41 × 10−2 | GABBR1 |
| electrophysiology of nervous system | 4.74 × 10−2 | GABBR1 |
* Fisher exact p-value which indicates the probability that the list of SNP-associated genes is not enriched for annotated function, using genes in IPA’s Knowledgebase as the reference set of genes.