Table 11.
Neurological functions implicated by QTN-associated genes in cDZ.
| Diseases or Functions Annotation | p-Value * | Genes |
|---|---|---|
| morphology of brain | 1.51 × 10−3 | DSCAM, LHX4, PRKN, TOP2B |
| abnormal morphology of abducens nerve | 1.73 × 10−3 | LHX4 |
| arrest in axonal transport of mitochondria | 1.73 × 10−3 | PRKN |
| quantity of catecholaminergic neurons | 1.73 × 10−3 | PRKN |
| delay in specification of corticotroph cells | 1.73 × 10−3 | LHX4 |
| excitation of striatal neurons | 2.59 × 10−3 | PRKN |
| startle response | 2.60 × 10−3 | PLCB1, PRKN |
| development of granule cell layer | 3.46 × 10−3 | CREM |
| function of central pattern generator | 3.46 × 10−3 | DSCAM, LHX4, PRKN, TOP2B |
| development of cortical subplate | 3.46 × 10−3 | TOP2B |
| abnormal morphology of locus ceruleus | 3.46 × 10−3 | PRKN |
| morphogenesis of dendrites | 3.67 × 10−3 | DSCAM, FMN1 |
| loss of hippocampal neurons | 4.32 × 10−3 | PLCB1, PRKN |
| development of central nervous system | 5.75 × 10−3 | CREM, PLCB1, PRKN, TOP2B |
| abnormal morphology of amacrine cells | 6.04 × 10−3 | DSCAM |
| sensorimotor integration | 6.04 × 10−3 | PRKN |
| abnormal morphology of substantia nigra | 6.90 × 10−3 | PRKN |
| abnormal morphology of neurons | 7.53 × 10−3 | DSCAM, LHX4, PRKN |
| abnormal morphology of nervous system | 8.50 × 10−3 | DSCAM, LHX4, PRKN, TOP2B |
| abnormal morphology of hypoglossal nerve | 9.48 × 10−3 | LHX4 |
| thickness of cerebral cortex | 1.03 × 10−2 | DSCAM |
| quantity of gonadotropes | 1.12 × 10−2 | LHX4 |
| innervation of motor neurons | 1.20 × 10−2 | TOP2B |
| abnormal morphology of brain | 1.22 × 10−2 | LHX4, PRKN, TOP2B |
| loss of neurons | 1.27 × 10−2 | PLCB1, PRKN |
| curvature of vertebral column | 1.80 × 10−2 | TOP2B |
| formation of brain | 1.83 × 10−2 | CREM, PLCB1, TOP2B |
| stratification of cerebral cortex | 1.89 × 10−2 | TOP2B |
| innervation of muscle | 1.89 × 10−2 | TOP2B |
| abnormal morphology of adenohypophysis | 1.97 × 10−2 | LHX4 |
| quantity of nerve ending | 2.14 × 10−2 | PRKN |
| guidance of motor axons | 2.23 × 10−2 | LHX4 |
| loss of dopaminergic neurons | 2.23 × 10−2 | PRKN |
| abnormal morphology of spinal nerve | 2.48 × 10−2 | LHX4 |
| fasciculation of axons | 2.56 × 10−2 | DSCAM |
| abnormal morphology of motor neurons | 2.82 × 10−2 | LHX4 |
| neuritogenesis | 3.00 × 10−2 | DSCAM, FMN1, TOP2B |
| abnormal morphology of subventricular zone | 3.07 × 10−2 | TOP2B |
| memory | 3.36 × 10−2 | CREM, PLCB1 |
| morphology of dendritic spines | 3.57 × 10−2 | DSCAM |
| quantity of dendritic spines | 3.99 × 10−2 | DSCAM |
| development of spinal cord | 4.49 × 10−2 | TOP2B |
| abnormal morphology of olfactory bulb | 4.57 × 10−2 | TOP2B |
| cell viability of cortical neurons | 4.74 × 10−2 | PRKN |
| electrophysiology of nervous system | 4.74 × 10−2 | PRKN |
* Fisher exact p-value which indicates the probability that the list of SNP-associated genes is not enriched for annotated function, using genes in IPA’s Knowledgebase as the reference set of genes.