Table 13.
Neurological functions of SNP-associated genes from dA.DZ vs. dNA.DZ case-control association analysis.
| Function Annotation | p-Value * | Genes |
|---|---|---|
| development of neurons | 5.50 × 10−6 | ADGRL3, CACNA1A, CACNG2, CNTN4, CTNND2, DCC, DMD, FER, GAS7, KLHL1, NTNG1, PALLD, PCM1, PIP5K1B, PIP5K1C, PRKCE, PRKG1, ROBO1, SLC12A2, SLIT3, TBCE |
| neuritogenesis | 3.57 × 10−5 | CACNA1A, CNTN4, CTNND2, DCC, FER, GAS7, KLHL1, NTNG1, PALLD, PIP5K1B, PIP5K1C, PRKCE, PRKG1, ROBO1, SLIT3, TBCE |
| axonogenesis | 2.58 × 10−4 | CACNA1A, CNTN4, DCC, NTNG1, PIP5K1C, PRKG1, ROBO1, TBCE |
| migration of neurons | 6.40 × 10−4 | ADGRL3, DCC, PCM1, PEX13, PIP5K1C, PRKG1, ROBO1, SLC12A2 |
| development of sensory projections | 7.83 × 10−4 | ROBO1, SLIT3 |
| pathfinding of neurons | 2.02 × 10−3 | DCC, ROBO1 |
| morphology of nervous system | 2.62 × 10−3 | ADGRA2, BBIP1, CACNA1A, CNTN4, DCC, KLHL1, MCPH1, NCOR2, PALLD, PCSK6, PEX13, PPARGC1A, ROBO1, SLC12A2, XRCC4 |
| guidance of axons | 4.61 × 10−3 | CNTN4, DCC, PRKG1, ROBO1, SLIT3 |
| abnormal morphology of forebrain | 4.80 × 10−3 | ADGRA2, BBIP1, DCC, NCOR2, PPARGC1A, ROBO1 |
| formation of dendrites | 4.83 × 10−3 | CACNA1A, GAS7, KLHL1, PRKG1, ROBO1 |
| developmental process of synapse | 5.28 × 10−3 | ADGRL3, CACNA1A, CACNG2, DCC, DMD, SLC12A2 |
| quantity of oxytocin neurons | 6.19 × 10−3 | DCC |
| synaptic transmission of stellate cells | 6.19 × 10−3 | CACNG2 |
| guidance of corticocortical axons | 1.23 × 10−2 | ROBO1 |
| quantity of vasopressin neurons | 1.23 × 10−2 | DCC |
| activation of Purkinje cells | 1.23 × 10−2 | CACNA1A |
| afterhyperpolarization of dopaminergic neurons | 1.23 × 10−2 | KCNN3 |
| size of hippocampal commissure | 1.23 × 10−2 | ROBO1 |
| startle response | 1.74 × 10−2 | CACNA2D3, CSMD1, PPARGC1A |
| inhibition of presympathetic neurons | 1.85 × 10−2 | SLC12A2 |
| fragmentation of myelin sheath | 1.85 × 10−2 | GALC |
| maturation of cerebellum | 1.85 × 10−2 | CACNA1A |
| turnover of synaptic vesicles | 1.85 × 10−2 | CACNA1A |
| density of synapse | 2.20 × 10−2 | CTNND2, GRIP1 |
| morphogenesis of neurites | 2.43 × 10−2 | CACNA1A, CNTN4, CTNND2, FER, GAS7, PALLD, PRKG1, ROBO1 |
* Fisher exact p-value which indicates the probability that the list of SNP-associated genes is not enriched for annotated function, using genes in IPA’s Knowledgebase as the reference set of genes.