Table 1.
The genes expression profiling of multidrug resistant-related genes in MCF7_DoxR compared to the MCF7_DoxS parental cells analyzed by RT2 profiler PCR array. A standard 2-fold change was used as arbitrary cut-off.
| Mechanism | Fold Change | |
|---|---|---|
| Upregulated (≥2-folds) | ||
| Drug efflux | ABCC1 | 2.4 |
| ABCC2 | 3.0 | |
| ABCC3 | 5.4 | |
| MVP | 2.5 | |
| Drug inactivation | CYP1A1 | 7.1 |
| CYP3A5 | 3.4 | |
| AhR | 4.1 | |
| ARNT1 | 2.3 | |
| SULT1E1 | 2.5 | |
| EPHX1 | 2.4 | |
| Cell cycle and cell death inhibition | PPARG | 14.5 |
| MET | 6.8 | |
| HIF1A | 6.2 | |
| CDKN1A | 3.6 | |
| RXRB | 2.8 | |
| IGF1R | 2.6 | |
| PPARD | 2.2 | |
| IGF1R | 2.6 | |
| XPA | 4.6 | |
| Growth factors receptors axes | ERBB4 | 21.5 |
| EGFR | 11.4 | |
| ERBB2 | 3.4 | |
| ERBB3 | 2.9 | |
| Myc | 2.1 | |
| Downregulated (≥2-folds) | ||
| Apoptotic regulator | Bcl-2 | −13.9 |