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. 2019 Jul 31;24(15):2792. doi: 10.3390/molecules24152792

Figure 1.

Figure 1

CG-745 ameliorates pulmonary fibrosis induced by bleomycin in mice. (A) Mice were instilled with bleomycin (2 mg/kg) intratracheally on day zero, and CG-745 (15 mg/kg, 30 mg/kg or 60 mg/kg) was intraperitoneally administered daily for 14 days. (B) Representative histological sections from lung tissues stained with hematoxylin and eosin (H&E) or Masson’s trichrome staining were shown from the control, bleomycin, and bleomycin + CG-745 (15 mg/kg, 30 mg/kg, or 60 mg/kg) group (magnification, ×200). (C) The wet/dry measurement was used to detect pulmonary edema. (D) Collagen content in the lung tissues was measured by a Sircol assay. Data are presented as mean ± SD, n = 5. * p < 0.01 versus control group. ** p < 0.05 versus bleomycin group.