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. 2019 Jul 29;20(15):3700. doi: 10.3390/ijms20153700

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CHK1 inhibition induces double-strand break (DSB)-mediated DDR signaling. (A) Immunoblot analysis of the indicated proteins in NB-39-nu cells after treatment with DMSO (0, NT), 1, 5, or 10 μM CHK1i (PF-477736) for 24 h. (B) Flow cytometric cell cycle analysis of cells treated as for (A) and then stained with propidium iodide (PI) to assess the cell cycle distribution. Upper panels show the PI histograms; lower panels show the proportion of cells in each phase of the cell cycle after the indicated treatments.