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. 2019 Jul 29;20(15):3700. doi: 10.3390/ijms20153700

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Combination treatment with either ATMi or DNA-PKi sensitizes NB cells to CHK1 inhibition. (A) CHK1i-insensitive NB-39-nu cells and (B) SK-N-BE cells were treated with DMSO (NT) or the indicated combinations of 0.175 μM CHK1i (PF-477736), 10 μM ATMi (Ku55933), and/or 1 μM DNA-PKi (NU7441) for 6 days. At the indicated times, cells were harvested and analyzed for cell viability (upper panels) or Giemsa staining (lower panel). Data are presented as the mean ± SD of four independent experiments. * p < 0.05.