Table 6.
Cellular cytotoxicity and potency testing in HEK293 mts17β-HSD10 cells.
| Compound ID | (−)-CHANA IC50 Values (μM) | LDH Cytotoxicity with 100 μM Compound | LDH Cytotoxicity with 25 μM Compound |
|---|---|---|---|
| 5 | 10.39 (95% CI 5.50–19.96) | 20.13 ± 4.26 | 13.28 ± 0.55 |
| 6 | 17.04 (95% CI 9.15–31.73) | 23.97 ± 3.32 | 23.54 ± 3.02 |
| 61 | 7.88 (95% CI 5.07–12.07) | 55.68 ± 2.55 | 28.83 ± 0.67 |
| 62 | 3.77 (95% CI 2.11–6.74) | 64.40 ± 3.62 | 27.25 ± 3.35 |
| 63 | 2.29 (95% CI 1.74–3.01) | 18.05± 0.96 | 15.98 ± 1.02 |
| 64 | - | 33.35 ± 2.92 | 22.83 ± 0.63 |
| 65 | 88.95 (95% CI 28.39–278.7) | 27.41 ± 2.65 | 11.27 ± 0.58 |
| 66 | - | 17.51± 0.46 | 13.59 ± 0.66 |
| 67 | - | 36.05 ± 1.75 | 22.68 ± 2.68 |
| 78 | - | 12.41 ± 0.64 | 11.34 ± 0.41 |